Vijaykrishna Dhanasekaran

Associate Professor
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Associate Professor Vijay Dhanasekaran leads the Pathogen Evolution Lab in the HKU-Pasteur Research Pole and HKU School of Public Health. Vijay has a BSc MSc and MPhil from University of Madras, India and a PhD (2005) in microbial ecology and evolution from University of Hong Kong. In 2006, he joined HKU Li Ka Shing Faculty of Medicine as a Postdoctoral Fellow in Virology. In 2010, Vijay joined Duke-NUS Graduate Medical School Singapore as Assistant Professor, before joining Monash University, Australia as Associate Professor in 2016. His lab is located within the HKU-Pateur Research Pole.


Genomic Epidemiology of Seasonal Influenza Circulation in China During Prolonged Border Closure from 2020 to 2021.

Off-season RSV epidemics in Australia after easing of COVID-19 restrictions.

Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination.

Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong.

Monitoring International Travelers Arriving in Hong Kong for Genomic Surveillance of SARS-CoV-2.

Influenza A(H3N2) outbreak in Cambodia and the Greater Mekong Subregion during the COVID-19 pandemic, 2020.

Air travel-related outbreak of multiple SARS-CoV-2 variants.

Genetic diversity of SARS-CoV-2 among travelers arriving in Hong Kong

Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases

Five challenges in the field of viral diversity and evolution

Reassortment and persistence of influenza A viruses from diverse geographic origins within Australian wild birds- evidence from a small, isolated population of Ruddy turnstones

Detection of Tioman Virus in Pteropus vampyrus Near Flores, Indonesia

Forensic genomics of a novel Klebsiella quasipneumoniae type from a neonatal intensive care unit in China reveals patterns of colonization, evolution and epidemiology

First description of antimicrobial resistance in carbapenem-susceptible Klebsiella pneumoniae after imipenem treatment, driven by outer membrane remodeling

CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features

Bayesian Evaluation of Temporal Signal in Measurably Evolving Populations

A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions

Positive epistasis between viral polymerase and 3’ untranslated region of its genome reveals epidemiological fitness of dengue virus

Influenza A-associated severe pneumonia in hospitalized patients- Risk factors and NAI treatments

Locally Acquired Human Infection with Swine-Origin Influenza A(H3N2) Variant Virus, Australia, 2018

Genome-Scale Phylogeny and Evolutionary Analysis of Ross River Virus Reveals Periodic Sweeps of Lineage Dominance in Western Australia, 1977-2014

Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity

Emergence of Influenza A(H7N4) Virus, Cambodia

Dengue disease severity caused by elevated secreted NS1 arising from a single T164S mutation

Antarctic penguins as reservoirs of diversity for avian avulaviruses

Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012–2018

Universally cross-reactive CD8+ T cell immunity across influenza A, B and C viruses

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.

Divergent human origin influenza viruses detected in Australian swine populations.

Evolution and spatio-temporal dynamics of Enterovirus A71 subgenogroups in Vietnam.

Evidence for viral interference and cross-reactive protective immunity between influenza B lineages.

Adaptive evolution during the establishment of European avian-like H1N1 influenza A virus in swine.

The Broad Host Range and Genetic Diversity of Mammalian and Avian Astroviruses.

Evidence for the introduction, reassortment and persistence of diverse influenza A viruses in Antarctica

Extended evaluation of virological, immunological and pharmacokinetic endpoints of CELADEN - a randomized controlled trial of celgosivir in dengue fever patients

The ecology and adaptive evolution of influenza A interspecies transmission

A role of influenza exposure history in determining pandemic susceptibility and CD8+ T cell responses

Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012

Differential age susceptibility to influenza B/Victoria lineage viruses in the 2015 Australian influenza season

Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection.

RNA virus reassortment - An evolutionary mechanism for host jumps and immune evasion

Ecological drivers of virus evolution - Astrovirus as a case study.

The contrasting phylodynamics of influenza B viruses.

Molecular epidemiology of influenza A H1N1 pandemic 2009 virus in humans and swine in Sri Lanka.

Adaptation of pandemic H2N2 influenza A viruses in humans.

Identification and molecular characterization of novel and divergent Hobi-like pestiviruses from naturally infected cattle in India.

Detection of evolutionarily distinct avian influenza A viruses in antarctica

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

The recent establishment of North American H10 lineage influenza viruses in Australian wild waterfowl and the evolution of Australian avian influenza viruses.

Inferring patterns of influenza transmission in swine from multiple streams of surveillance data.

Surveillance and characterization of avian influenza viruses from migratory water birds in eastern Hokkaido, the northern part of Japan, 2009-2010.

No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine.

Genetic analysis.

Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans.

Long-term evolution and transmission dynamics of swine influenza A viruses.

Ancient origins determine global biogeography of hot and cold desert cyanobacteria.

The emergence of pandemic influenza viruses.

Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development.

Surveillance and analysis of avian influenza viruses, Australia.

Rapid detection of reassortment of pandemic H1N1/2009 influenza virus.

Reassortment of pandemic H1N1/2009 viruses in swine.

Dating the emergence of pandemic influenza viruses.

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic.

Evolutionary dynamics and emergence of panzootic H5N1 influenza viruses.

Evolutionary insights into the ecology of coronaviruses.


Pathogen Evolution Lab in HKU